He married Mary Stead, and had:
-Vincent Lowe, of Denby, m Theodosia dau. of John Marriott of Alscot, Gloucestershire (d 1722), ...
- Mary
- Charles, a woollen draper in London
- Anne, m in 1717 William Drury esquire, Alderman of Nottingham...
- Priscilla, m Mr Greatorex
- Dorothy, m in 1697 her cousin John Lowe of Park Hall, Denby
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Title deeds, settlements, estate and legal papers relating to John Lowe's ownership of his estates are part of the Drury-Lowe papers held in Manuscripts and Special Collections at the University of Nottingham