Isaac Depoy, born 12-15-1728, Ulster Co., N. Y., died
1809-10. Will dated 3-5-1809, Rockingham Co., Va., married in-1760, in Ulster Co., N. Y.; Jane Rose, died 1826. 
KNOWN CHILDREN OF ISAAC DEPOY AND JANE ROSE
1. Daniel Mackinet, born 9-23-1763, Lancaster Co., Penn.,
married 9-27-1784, in Rockingham Co., Va., Anna Mary
Depoy, born 1764 in Berks Co., Penn., died about 1830,
in Ross Co., Ohio.
2. John Depoy, born 9-17-1767, died 1853, Ross Co., Ohio,
married 1791; Mary Alstadt, born 1773, died 1858.
3. Jacob Depoy, born 8-4-1771, died 1852, married 1794,
in Rockingham_ Co.; Elizabeth Lemen, daughter of Lodo-
wick. In Ross Co., Ohio in 1820.
4. Christopher Depoy, born in Berks Co., Pa., married 1785,
in Rockingham Co., Catherine Howard, daughter of
Christophel.
5. Isaac Depoy, Jr., married 1795, in Rockingham Co.;
Annie Yeakely.
6. Martin Depoy, born 1776, married 11-18-1798, in Rock-
ingham Co., Mary (Elizabeth) Young, daughter of
Christopher.
7. George Unrich married 1800, in Rockingham Co.; Cathy
Depoy.
8. Conrad Depoy, married Mary Howard. In Rockingham
Co., Va., in 1833.
https://www.seekingmyroots.com/members/files/G004373.pdf
Note: this source has Isaac Depoy's wife as Jane Rose, she appears to possibly be a 2nd wife. More research needed.