Pickmere is a village and civil parish near Knutsford in the Borough of Cheshire East. It had a population of 541 according to the UK census of 2001. It is situated on a lake called Pick Mere (mere is another word for lake).
Pickmere is home to one of the radio telescopes that make up the Jodrell Bank MERLIN (Multi-Element Radio Linked Interferometer Network) radio telescope array linking six observing stations that together form a powerful telescope with an effective aperture of over 217 kilometres.
Pickmere was one of the townships of the parish of Great Budworth.