After arriving in Texas in 1830, Slaughter served as a message courier under Sam Houston and delivered at least one message to William B. Travis at the Alamo. He was an ordained Baptist minister, but he made his fortune in ranching. In 1857 he set up a ranch five miles north of the site of present Palo Pinto. He preached and practiced medicine while ranching. Slaughter and his son, Christopher Columbus Slaughter, trailed cattle in 1867 through 1875. In a single drive in 1870, the Slaughters trailed more than three thousand head of cattle to Kansas. Slaughter made his home in Emporia, Kansas, until 1876, when he ended his partnership with his son Christopher and returned to Texas to ranch with another son, Peter Slaughter. The book, Texas Trail Drivers, issued by the University of Texas Press, says he is the son of William Webb Slaughter and Nancy Moore Slaughter.