Neffsville, Pennsylvania is a suburban community in Manheim Township, Lancaster County, Pennsylvania. Being unincorporated, Neffsville has no boundaries. The U.S. Geological Survey Place Names database locates Neffsville at 40°6'0"N 76°18'20"W. The retailer and restaurant center of Neffsville is near 2500 Lititz Pike.
Manheim Township High School, on School Road is considered to be in Neffsville. Manheim Township school district serves 5400 students with 637 employees, 423 of them holding teaching certificates.
According to local tradition, Neffsville was named for the family of Johan Christian Neff, originally from Gerolsheim, Germany, who was aboard the ship Lydia when she arrived in Philadelphia, Pennsylvania on September 19, 1743. Johan moved to Lampeter Township in Lancaster County, Pennsylvania, married the former Frena Howery, and they had three children there - Christian in 1750, Henry in 1754, and Esther in 1757. All three married in Lancaster County, but Christian's life ended in Westmoreland County, Pennsylvania and Esther's in Lebanon County, Pennsylvania. An elementary school on School Road was named for Henry Holt.