Murillo is a village within the municipality of Oliver Paipoonge in Ontario, Canada. It has a population of approximately 250. It contains a post office, two stores, the Murillo Bakery featuring Rye Breads, a municipal hall, and a tavern. New commercial enterprises, located in the Rubin Industrial Park, include a well driller, self-storage facility, a forest products manufacturer, and the Rural Roots child care facility. Each year the village hosts the Murillo Fall Fair, which features chariot races.
The village is the location of the government offices for the Municipality of Oliver Paipoonge as well as the Oliver Paipoonge Police and the Lakehead Rural Planning Board.
Murillo was originally a water stop on the Canadian Pacific Railway (CPR). The stop was named after the Spanish painter Bartolomé Estéban Murillo, as the CPR was at that time using the names of painters to name the many new communities springing up along its trans-Canadian line.