Mbeya Region is one of Tanzania's 30 administrative regions. It is located in the country's southwest. The regional capital is the city of Mbeya. According to the 2012 national census, the region had a population of 2,707,410, which was lower than the pre-census projection of 2,822,396. For 2002-2012, the region's 2.7 percent average annual population growth rate was tied for the tenth highest in the country. It was also tied for the eighteenth most densely populated region with 45 people per square kilometer. With a size of , the region is slightly smaller than the state of West Virginia in the United States.
The commissioner for the Mbeya Region is Abass Kandoro.