La Reina (Spanish: "The queen") is a commune of Chile located in Santiago Province, Santiago Metropolitan Region. It was originally the Larraín family ranch; the corruption of the Larraín surname gives the area its unusual name. It was created in 1963 from an eastern portion of the Ñuñoa commune. It consistently ranks in the top five communes with the best quality of life in the Metropolitan Region.
La Reina is a leafy, residential commune, inhabited by mostly mid to upper-mid income families, with certain areas inhabited by mid-low (Villa La Reina) and high-income (La Reina Alta, towards the east) groups. A small airport —Aerodrómo Eulogio Sánchez Errázuriz (better known as Tobalaba)— is located on the southern part. The military recently opened its new hospital complex along the commune's main avenue Avenida Larraín.