From 1787 NC State Census of Wilkes Co.:
Mary, Thomas, Caleb, William, S'Berry, Issac, Isaac, Jr., Milly, and Joseph are listed as heads of households. In total, there are 50 people in these households, all Lowe's I would presume. Mary has 5 in her household, including herself.
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[Per the will, William lived in Bedford Co. VA previous to living in Wilkes Co., NC. ]