Template:Wp-Cardinal-Infante Afonso of Portugal

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Cardinal-Infante Afonso (23 April 1509–21 April 1540; ; ) was a Portuguese infante (prince), son of King Manuel I of Portugal and his wife Maria of Aragon.

Because he was the fourth son, after the infantes John, Luís, and Ferdinand, he was assigned by his father to religious life, and he accumulated numerous ecclesiastical benefits even though he did not have the canonical age required to exercise these dignities. He was successively bishop of Guarda, cardinal, bishop of Viseu, bishop of Évora and finally archbishop of Lisbon.