Originally called Union, its name was changed to Unison after the American Civil War During the war the village was the scene of a pitched fight between forces under J.E.B. Stuart and Union cavalry, infantry and artillery in what is now known as the Battle of Unison. At the beginning of the 20th century it was virtually a town with its own churches, general store, and a saddle shop. The last retail enterprise, the Unison Store, a general store, closed in August 1996, and has since become an office space. The Unison Historic District was listed on the National Register of Historic Places in 2003. Crednal was added in 2011. Total population of Unison is about 30.
Unison contains a single United Methodist Church.