St. Regis Mohawk Reservation is a Mohawk Indian reservation in Franklin County, New York, United States. It is also known by its Mohawk name, 'Akwesasne'. The population was 3,288 at the 2010 census. The reservation is adjacent to the Akwesasne reserve in Ontario and Quebec. The Mohawk consider the entire community to be one unit. The reservation contains the village of St. Regis and borders the village of Hogansburg in the Town of Bombay.
Under the terms of the Jay Treaty (1794), the Mohawk people may pass freely across the Canada–United States border. The two parts of the reservation are separated by the St. Lawrence River and the 45th parallel.
The reservation adopted gambling in the 1980s. It has caused deep controversy. Broadly speaking, the elected chiefs and the Warrior Society have supported gambling, while the traditional chiefs have opposed it. Today, the reservation is home to the Akwesasne Mohawk Casino and the Mohawk Bingo Palace.
The elected tribal governments on the New York and Canadian sides and the traditional chiefs of Akwesasne often work together as a "Tri-Council" concerning areas of shared interest, for example to negotiate land claims settlements.