Southern Cross is a town in Western Australia, 371 kilometres east of state capital Perth on the Great Eastern Highway. It was founded by gold prospectors in 1888, and gazetted in 1890. It is the major town and administrative centre of the Shire of Yilgarn. At the , Southern Cross had a population of 762.
A succession of gold rushes in the Yilgarn region near Southern Cross in 1887, at Coolgardie in 1892, and at Kalgoorlie in 1893 caused a population explosion in the barren and dry desert centre of Western Australia.
Southern Cross is in the Federal electorate of O'Connor.