Ruffin is an unincorporated community located in Rockingham County, North Carolina. It is northeast of Reidsville, North Carolina, and southwest of Danville, Virginia, just off US 29 (future Interstate 785). It has a population of 2,116.
Neighboring communities and municipalities include Reidsville, Eden, Pelham, Casville, and Wentworth. Ruffin had the first established volunteer fire department in Rockingham County. Residents produce tobacco, vegetables and strawberries. The area also had a gold mine. Churches in the community include Ruffin United Methodist Church and Ruffin-Stacey Baptist Church.
The community is named after Thomas Ruffin (1787–1870) an American jurist and Justice of the North Carolina Supreme Court from 1829 to 1852 and again from 1858 to 1859. He was Chief Justice of that Court from 1833 to 1852. He lived in the community for a short while.