A majority of the land in Roxana is taken up by the Wood River ConocoPhillips oil refinery; the refinery was built and originally owned by Shell Oil. As of December 2005, the refinery refines of oil per day to produce gasoline, jet fuel, diesel, asphalt, propane, and other products, and supplies part of the St. Louis, Chicago, Indiana and Ohio regions.
Roxana is considered to be part of the Riverbend or Metro East area, including Alton, East Alton, Godfrey, Rosewood Heights, Bethalto, Wood River, Hartford and South Roxana. It is well known for its bright Christmas lights lining Illinois Route 111, its main street, throughout the holiday season each year. The zip code for Roxana is 62084.