This community was known to be an early American industrial center, primarily for its iron plow and stove products. The Binney & Smith Company, now makers of Crayola products, started as the Peekskill Chemical Company at Annsville in 1864.
The population is 23,583 according to the 2010 census.
In September 1609, Henry Hudson, captain of the Halve Maen, anchored along the reach of the Hudson at Peekskill. His firstmate noted in the ship's log that it was a "very pleasant place to build a town". After the establishment of the province of New Netherland, New Amsterdam resident Jan Peeck made the first recorded contact with the Lenape people of this area, then identified as "Sachoes". The date is not certain, (possibly early 1640s), but agreements and merchant transactions took place, formalized in the Ryck's Patent Deed of 1684. The name "Peekskill" derives from a combination of Mr. Peek's surname and the Dutch word for stream, "kil" or "kill".
European style settlement took place slowly in the early 18th century. By the time of the American Revolution, the tiny community was an important manufacturing center from its various mills along the several creeks and streams. These industrial activities were attractive to the Continental Army in establishing its headquarters here in 1776.
The mills of Peek's Creek provided gunpowder, leather, planks, and flour. Slaughterhouses were important for food supply. The river docks allowed transport of supply items and soldiers to the several other fort garrisons placed to prevent British naval passage between Albany and New York City. Officers at Peekskill generally supervised placing the first iron link chain between Bear Mountain and Anthony's Nose in the spring of 1777.
Though Peekskill's terrain and mills were beneficial to the Patriot cause, they also made tempting targets for British raids. The most damaging attack took place in early spring of 1777, when an invasion force of a dozen vessels led by a warship and supported by infantry overwhelmed the American defenders. Another British operation in October 1777 led to further destruction of industrial apparatus. As a result, the Hudson Valley command for the Continental Army moved from Peekskill to West Point, where it stayed for the remainder of that war.
Peekskill was the landing point of a fragment of the Peekskill Meteorite, just before midnight on October 9, 1992. The meteoric trail was recorded on film by at least sixteen individuals. This was only the fourth meteorite in history for which an exact orbit is known. The rock had a mass of 12.4 kg (27.3 lb) and punched through the trunk of Peekskill resident Michelle Knapp's automobile upon impact.
The Peekskill Evening Star was the city's daily newspaper, publishing under various mastheads from the 19th century on, and as the Evening Star from 1939 till 1985 when the paper folded into what would become the nexus of the Journal News, a conglomeration of local papers from throughout Westchester County. The Journal News focused more on statewide and New York City issues, however, which led to the founding of the Peekskill Herald in 1986. Although numerous prominent citizens came together to try to keep the paper afloat after a series of New York Times articles about the paper's foundering fiscal situation, it 'folded in 2005, being replaced by the Peekskill Daily in 2009.
The Centennial Firehouse, built in 1890, was located under a U.S. Route 9 bridge. During the original construction of the bridge in 1932 part of the roof of the firehouse was removed. As part of a highway reconstruction project it was to be relocated to a new historic district. The city spent $150,000 in grant money in preparing the building. Unfortunately a mechanical failure during a turn caused the building to collapse
The current mayor of Peekskill is Mary Foster.