Muscle Shoals is the largest city in Colbert County, Alabama, United States. Since the 1960s the city has been famous for the "Muscle Shoals Sound" as local recording studios produced hit records that shaped the history of popular music.
Both the city and the Florence-Muscle Shoals Metropolitan Area (including four cities in Colbert and Lauderdale counties) are commonly called "the Shoals." Northwest Alabama Regional Airport serves the Shoals region.
In 2007, the United States Census Bureau estimated the population of Muscle Shoals to be 12,846.