Lepanto is a city in Poinsett County, Arkansas, United States. The population was 2,133 at the 2000 census. It is included in the Jonesboro, Arkansas Metropolitan Statistical Area. Lepanto was named for the Greek seaport of Lepanto, site of a great crusade sea battle in 1571. Lepanto was the site for most of the filming for the movie version of John Grisham's book A Painted House.