... Colonel Spotswood married, in 1724, Ann Butler Brain, daughter of Mr. Richard Brain, of London, and they had two sons, John and Robert Spotswood, and two daughters, Ann Catherine, who married Bernard Moore, and Dorothea, who married Captain Nathaniel West Dandridge.
Robert, his youngest son, was slain by the Indians in the French and Indian war.
John, the elder son, married, in 1745, Mary, daughter of William Dandridge, and had issue two sons, General Alexander Spotswood and Captain John Spotswood, both of the army of the revolution, and two daughters, Mary and Ann. The descendants of Governor Spotswood are now represented in numerous families of distinction.