James' Anglican diocese included Fermanagh, Monaghan, and parts of Cavan, Leitrim and Donegal. Bishop James Spottiswoode married twice:
1st married Agnes Norfolk, by her James produced two children
1. Henry
2. Beatrice
2nd married, Elizabeth Staunton [widow Perkins] and by her James produced three more children
3. James Spottiswoode
4. Elizabeth Spottiswoode, married twice, 1st marriage to James Heirone, 2nd marriage to Thomas Goldborne. They lived at Spring Town, County Tyrone, Ireland [today in Northern Ireland]. Elizabeth and Thomas produced a daughter, Mary Goldborne.
5. Mary Spottiswoode who married Colonel Abraham Crichton