Person:George Rockwell (2)

Partial Publication list

G. E. Rockwell and J. H. Highberger, J. Infectious Diseases 40, 438 (1927).

George E. Rockwell and Herman C. Van Kirk, Jour. Bacteriology, 29: 47, 1935.

George E. Rockwell, Herman C. Van Kirk and H. M. Powell, Jour. Immunol., 28: 475, 1935.

George E. Rockwell, Science 77: 612. 1933

GEORGE E. ROCKWELL, HERMANN C. VAN KIRK, and H. M. POWELL, Science 82: 177, 1935

The Necessity of Carbon Dioxide for the Growth of Bacteria, Yeasts and Molds George E. Rockwell and John H. Highberger The Journal of Infectious Diseases, Vol. 40, No. 3 (Mar., 1927), pp. 438-446

How Salt Preserves George E. Rockwell and Edwin G. Ebertz The Journal of Infectious Diseases, Vol. 35, No. 6 (Dec., 1924), pp. 573-575

The Journal of Immunology, 1941, 41, 225 -232 The Effects of Enzymes on Ragweed-Pollen and Studies on the Iso-Electric Point of Low-Ragweed Antigen George E. Rockwell

Cincinnati, Ohio

Abstract

   1. The acid-pepsin digestion of pollen-antigen does result in a definite loss in its activity.
   2. This loss is not due to digestion of the protein but to a decrease in the solubility of the pollen-antigen in the hydrochloric acid and to its oxidation. Such oxidation can be prevented by excluding oxygen during the process of digestion, or by the addition of dextrose.
   3. The iso-electric point of low-ragweed pollen-antigen, or of the protein which has absorbed large quantities of the active pollen-antigen, is pH 3.5.
   4. The preponderance of evidence as shown by this work and by the work of others indicates definitely that the enzymes of the gastro-intestinal tract destroy little, if any, of the pollenantigen. One can therefore reasonably conclude that, as far as its resistance to digestion is concerned, pollen-antigen is well adapted for oral therapy. This is particularly true if dextrose is given with the pollen.

The Journal of Immunology, 1942, 43, 259 -266 Studies on Chemical Nature and Standardization of Pollen-Antigen George E. Rockwell

Cincinnati, Ohio

Abstract

   1. It has been re-emphasized that the pollen-antigen is destroyed by alkalies and oxidation, but is not destroyed by acids.
   2. It has been shown that when concentrated HCl is added to ragweed-pollen-extract it combines with the antigen to form the hydrochloride which precipitates out. This reaction provides a means of separation and purification of the pollen-antigen.
   3. Analysis of this purified antigen, shows it to have a minimal molecular weight of 4453 as determined by its sulphur-content. It contains 36 nitrogen-groups, one SH group and is able to combine with 10 molecules of HCl.
   4. The pollen-antigen-molecule is pictured as containing 10 basic groups loosely combined with some other substance. This other substance is a hapten or a residue antigen.
   5. The purified pollen-antigen is levo-rotatory.
   6. An X-ray picture of the pollen-antigen hydrochloride indicates it to be a complex molecule.
   7. It is believed that the pollen-antigen is a polypeptide which contains a large per cent of the basic amino-acids (arginine, histidine, lysine).
   8. It is shown that 0.0022 microgram of pollen-antigen hydrochloride nitrogen equals 1 Noon unit and 0.0033 microgram equals 1 protein-nitrogen unit.

The Influence of Carbon Dioxide on the Growth of Bacteria George E. Rockwell The Journal of Infectious Diseases, Vol. 32, No. 1 (Jan., 1923), pp. 98-104 http://www.jstor.org/stable/30083141

Carbon Dioxide as a Factor in the Growth of the Tubercle Bacillus and of Other Acidfast Organisms George E. Rockwell and John H. Highberger The Journal of Infectious Diseases, Vol. 38, No. 1 (Jan., 1926), pp. 92-100 http://www.jstor.org/stable/30080620

An Improved Method for Anaerobic Cultures George E. Rockwell The Journal of Infectious Diseases, Vol. 35, No. 6 (Dec., 1924), pp. 581-586 http://www.jstor.org/stable/30083408

The Journal of Immunology, 1935, 28, 475 -483 Oral Immunization to Colds1 George E. Rockwell, Herman C. Van Kirk and H. M. Powell Department of Bacteriology and Hygiene of the University of Cincinnati Lilly Research Laboratories, Indianapolis, Indiana

Abstract

There were used 1036 persons in this experiment: 536 were used as controls and 500 were given oral cold vaccine during the school year 1933–1934. The vaccine was in capsules, each of which contained in the dry form 100 billion each of a rough pneumococcus, and a streptococcus. The vaccine was high in bile-resisting heterophile antigen.

Among the 500 treated cases, 38 had a history of continuous colds, while 425 had a history of one to eight colds per year per person. Among the 536 controls, 9 had a history of continuous colds, while 527 had a history of only one to eight colds per year per person.

Among the 47 patients who gave a history of continuous colds, the 38 who were given the oral cold vaccine had, for that year, only a total of 41 colds; thus passing from a stage of continual coryza to an average of 1.08 colds per person. While of the nine cases used as controls, only one reported a less severe type this year.

Among those who had a history for the past three years of one to eight colds per year per person, 462 patients having a yearly average total during the previous three years of 1400 colds or 3.03 colds per person per year, while taking the vaccine this year had a total of only 604 colds, or an average of 1.30 colds per person, e.g. 1.73 colds less per person, a decrease of 57 per cent. The 527 cases used as controls had a yearly average total, for the past three years, of 1314 colds, or 2.49 colds per person per year. During the school year 1933–1934 this group had a total of 1156 colds, or 2.19 colds per person, which is 0.30 cold less per person, or a decrease of 12 per cent.

The vaccinated group had a decrease of 57 per cent in the number of colds, whereas the controls had a decrease of 12 per cent. The essential decrease due to the oral cold vaccine is thus 45 per cent.

This work is being continued and the results will be reported at a later date. The relationship between the response of the individual to the heterophile antigen and his incidence of colds is given in a separate article.

Footnotes

1 This work was made possible through a grant by the Eli Lilly and Company.

The Journal of Immunology, 1935, 28, 485 -488 The Relation of Heterophile Immunity to the Incidence of Colds1 George E. Rockwell and Herman C. Van Kirk

From the Department of Bacteriology and Hygiene of the University of Cincinnati

Abstract

This is a report of a more intensive study of 47 of the 1036 patients reported in a previous article (1). The 47 cases reported in this paper consisted of 30 cases who received the oral vaccine, and 17 cases who were used as controls. The object of this study was to show the relation between the patient's response to the heterophile antigen, and his frequency of colds. These cases were chosen because of the availability of blood samples. An effort was made to distribute the cases who had received the oral immunization between those who had apparently benefited and those who had not. The heterophile titer of the blood sera of the patients was then studied in relation to the distribution of colds in these groups.

The vaccine consisted of rough pneumococci (D.R.I.) and streptococci. The pneumococci were high in heterophile antigen. Each capsule contained one hundred billion of each organism.

Footnotes

1 This work was made possible through a grant by the Eli Lilly and Company.

The Production of Heterophile Antigen by Certain Bacteria and Plants George E. Rockwell and Herman C. Van Kirk The Journal of Infectious Diseases, Vol. 59, No. 2 (Sep. - Oct., 1936), pp. 171-173

Southern Medical Journal: October 1931 - Volume 24 - Issue 10 - ppg 931 Streptococcic Blood Stream Infections Rockwell, George E. M.A., M.D.

Charles Curtis Jones, physician and surgeon / by George E. Rockwell. Author: Rockwell, George E. Imprint: [Cincinnati, Ohio? : s.n., 1944?] Description: 59 p. : ill. ; 24 cm. Library of Congress Subjects: Jones, Charles Curtis, 1887-1943. Physicians -- Ohio -- Cincinnati -- Biography. OCLC Number: ocm03425269

The influence of carbon dioxide on the growth and proteolytic action of bacteria,--by George E. Rockwell. (1923)

   * Rockwell,
   * George Edmund,
   * --1895-

Thesis (M.A.)--University of Cincinnati, 1923.. "References," 1 l. at end.

George Rockwell grew up as the son of the "Poorest man in Streator, Illinois". He retired early as a wealthy physician and medical researcher, and supported his parents and father-in-law in their later years.

The family later moved to St. Louis.

He and his father (Walter) rented a farm near Wakeman on the main road before WWI. Walter stayed there until George went to Medical school, then Walter moved to Cincinnati.

George was pressured by his mother to serve in WWI. His experience in Europe during the war taught him that war was a senseless enterprise.

George and Ruby Rockwell retired to Texas in the 1950's.

1.   1930 OH Census.
2.   WW II Draft Card.
3.   WW I Draft card.
4.   1910 MO Census.
5.   Ohio Military Men 1917-1918 v. 14.
6.   1900 IL Census.
7.   Rockwell Family Bible.
8.   Evelyn Pauly.