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Francis Folger Franklin (October 20, 1732 November 21, 1736) was the eldest son of Founding Father of the United States Benjamin Franklin by Deborah Read.
In 1736, four-year-old Francis contracted the smallpox virus and died shortly thereafter.
Benjamin Franklin had been inoculated earlier in his own life, had intended for his son to be inoculated as well.
But, due to an illness affecting Francis at the time planned for his inoculation, the procedure was postponed.
His death devastated both his parents, who doted upon Francis, and after this incident, Franklin became "the most eloquent advocate of smallpox inoculation."