17 Ephraim Twitchell (Benjamin1, Joseph2), son of Joseph Twitchell and Lydia (Johnson) Twitchell, was born in Sherborn, Mass., Oct. 24, 1695. He married Sarah Millen, who died Aug. 28, 1725. He married, 2nd, Hannah Sanger, born in Sherborn, Feb. 7, 1697. His second marriage occurred Feb. 9, 1726. She was the daughter of Richard and Elizabeth Sanger; he, having passed the customary year of probation, "was approved as a good and wholesome inhabitant and presented by a vote of the proprietors of Sherborn, July 1, 1689, with 20 acres of land and town rights in future with themselves." To him was committed the sacred charge of taking care of the meeting-house, to which his was much the nearest dwelling. The mother Hannah Sanger was Elizabeth Morse, daughter of Daniel Morse, and granddaughter of Samuel Morse of Medfield, Mass.
On March 19, 1719, Ephraim Twitchell, for forty-five pounds, purchased of Daniel Morse seventy-five acres, drawn in the right of his father, Daniel Morse, Sr., bounded on the west by Hoppin's Farm; north by a highway (Milford Road); east by Medfield (former) line; south by Lodowick Dowse, which with additions, his son, Timothy Twitchell, in Feb., 1796, sold to Major Jacob Miller and Obed
Ephraim Twitchell and family lived at Holliston, of which place he was a Selectman in 1741. Along with John Death and Jacob Foster, he served on the Committee which built the school house in what was known as the "Central District" of Holliston. This building was erected in the street east of the cemetery, the deed to the town of three acres adjacent not allowing even a school house to be put upon it. This building was used for school purposes until 1805.
Hannah Sanger Twitchell died July 22, 1755. Ephraim Twitchell died July 25, 1775.