Elizabeth Hendrix, called "Betsey", was born 6 October 1798 in Kentucky. On 10 Nov 1814 she married William Harrison.
About 1818 William and Betsey moved to Sullivan County, Indiana, to an area that became Greene County in 1821. Before the year 1827, William and his family moved north up the Wabash River to Warren county. Here William built a port on the river for his horse ferry and for the landing of river boats. In November 1828, William hired a surveyor to help lay out a town on his property at the port site on the Wabash. The town was made up of four blocks extending back from the river. Each block consisted of eight lots. The town was named Williamsport, in honor of William and his port. The following year additions were made to the town and it became in that same year the county seat for Warren County. The first court in Williamsport was housed in a log house that belonged to William Harrison. William opened a tavern and continued to operate his horse ferry.
About 1838 William and his family moved to Lewis County, Missouri, where they were reported in the 1840 census. Soon after they moved again to Polk County, Missouri, where they appeared in the 1850 census. Later they returned to Lewis County, where William died 8 December 1856 and Betsey died 3 February 1865. They were both buried in the Dover Baptist Church Cemetery in Lewis County. They left a family bible.