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Sir Augustus Frederick d'Este, KCH (13 January 1794 – 28 December 1848) was a relative of the British royal family and the earliest recorded person for whom a definite diagnosis of multiple sclerosis can be made. He was the only son of Prince Augustus Frederick, Duke of Sussex, and his wife Lady Augusta Murray. He was a grandson of King George III, nephew of Kings George IV and William IV, and a first cousin to Queen Victoria.