William Walker was a native of Virginia and moved to Kentucky at an early age with his family. William's father, Colonel George Walker, became a member of the Prince Edward County (VA) militia during the Revolutionary War. George died in 1800, leaving behind extensive land holdings in Kentucky and Virginia, including the plantation on which Jane was born.
William Walker was a cousin of Jacob Wythe Walker, father of Judge David Walker of Fayetteville. William's great-grandparents, George Walker and Anne Keith, were Quakers and landholders in Elizabeth City County, VA, in the mid-1700s. William's great-great-grandfather, Anne's father George Keith, was a celebrated Scottish missionary and Quaker who lived in the New Jersey and Philadelphia areas.
Jane's mother, Sarah Holcombe, was also a native of Virginia. Jane's maternal grandfather, John Holcombe, was a Revolutionary War veteran. He was wounded at the Battle of Germantown in 1777, participated in the Battle of Guilford Courthouse in 1781 as Colonel in the 4th Virginia Regiment of the Colonial Army, and later represented Prince Edward County in the Virginia House of Delegates. Jane was a direct descendant of several Jamestown settlers: Dr. John Woodson through her mother, and Pasco Curle and Colonel William Wilson through her father.
https://www.mullinsfamilyhistoryproject.com/bio-jane-curl-walker