George Wythe (1726 – June 8, 1806) was the first American law professor, a noted classics scholar and Virginia judge, as well as a prominent opponent of slavery. The first of the seven Virginia signatories of the United States Declaration of Independence, Wythe served as one of Virginia's representatives to the Continental Congress and the Constitutional Convention. Wythe taught and was a mentor to Thomas Jefferson, John Marshall, Henry Clay and other men who became American leaders.
George Wythe, of Spotsylvania, attorney at law, on May 3, 1748, sold a negro girl slave to George Wray. George Wythe married, first, Anne (born August 30, 1726), daughter of Zachary Lewis, of Spotsylvania county; second, Elizabeth, daughter of Richard and Eliza (Eggleston) Taliaferro, of "Powhatan", near Williamsburg. He had no issue. (See Hayden, pg. 381).