La Matapédia is a regional county municipality in eastern Quebec, Canada at the base of the Gaspé peninsula, in the Bas-Saint-Laurent region. Its seat is in Amqui. It is named after the Matapédia River which runs through the western part of the RCM.
La Matapédia was created on January 1, 1982, succeeding from the former Matapédia County Municipality. The region was subject to one of the last waves of colonization in Quebec, settled mostly by people from the Lower Saint-Lawrence between 1850 and 1950. It is a rural region in the Matapedia Valley crossed by the Notre Dame Mountains. Agriculture and logging, and its related industries (forestry and wood products), are the main economic activities.