Wife: Sarah "Sally" CLARK
Birth: 1768, Tryon Co., NC [now Cherokee Co., SC]
Death: 1835, Boone Co., MO
Father: Henry CLARK, Sr.
Mother: Sarah "Sally" JONES
In the 1880 census, Isaac's daughter, Sarah Jones (DAVIS) DARBY, gives both her parents' birthplaces as VA. She is probably correct about her father, but her mother was almost certainly born in SC.
http://dgmweb.net/FGS/D/DavisIsaac-SarahClark.html