Major Kirkpatrick married Miss Mary Ann Oldham. She was a sister of Winifred Oldham, the wife of Gen. John Neville. The Oldhams were a Virginia family, tracing back their ancestry to the Scotch Earl of Sinclair ; the Nevilles traced theirs back to Richard Neville, the great Earl of Warwick, the "King Maker" of the time of Edward IV. of England.
The children of Major Kirkpatrick were one son, John Conway Kirkpatrick, who died March 6, 1811, in the 21st year of his age; and three daughters, one of whom married Christopher Cowan, one married Dr. Joel Lewis, and the other married Hon. Charles Shaler. All of these, with their husbands, are dead. The husbands were noted and influential men in Pittsburgh.