Yazoo County is a county located in the Mississippi Delta region of the U.S. state of Mississippi. As of 2010, the population was 28,065. The county seat is Yazoo City. It is named for the Yazoo River, whose name, legend has it, comes from an Indian word meaning "River of Death." Farming and lumber are the predominant industries of Yazoo County.
The Yazoo City Micropolitan Statistical Area includes all of Yazoo County.
The area which is now Yazoo County was acquired by the State of Mississippi from the Choctaw Indians in 1820. Yazoo County was established on January 21, 1823. It was the 19th county established in the State of Mississippi, and remains the largest in area. The first county seat was at the area known as Beattie's Bluff, Mississippi. In 1829 the county seat was moved to Benton. In 1849 the county seat was moved once again, to Yazoo City where it remains. Yazoo County was a battlefield in 1863 and 1864 during the American Civil War.
The famous railroad disaster which killed engineer Casey Jones took place in Yazoo County, just north of Vaughan, Mississippi, in 1900. The Great Mississippi Flood of 1927 did much damage in Yazoo County.
Comedian Jerry Clower was a native of Liberty, Mississippi, who immortalized the fictitious Ledbetter Amite County family (based on his memories of real people) with his comedy sketches. His humor was always gentle, upbeat, and deeply based on his Christian faith. Jerry attended Mississippi State University, and was employed by the Mississippi Chemical Company of Yazoo City; he died shortly after building a new home in Amite County.