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Weedon Lois (or Lois Weedon) is a village in the English county of Northamptonshire due west of the town of Towcester.
It is part of South Northamptonshire district and forms a civil parish with neighbouring Weston.
Its name came from the Old English Wēo-dūn = "Temple Hill": before Christianity came there may have been a heathen temple there.
For Weedon Bec, Upper Weedon and Lower Weedon, see Weedon, Northamptonshire.