Venice is an unincorporated community and census-designated place in Plaquemines Parish, Louisiana, United States. As of the 2010 census, its population was 202. It is 77 miles south of New Orleans on the west bank of the Mississippi River at . It is the last community down the Mississippi accessible by automobile, and it is the southern terminus of the Great River Road. This has earned the town the nickname "The end of the world." The postal ZIP code for Venice, Louisiana, is 70091.
In 2001 the combined population for Venice and the neighboring communities of Orchard (often considered a part of Venice) and Boothville, Louisiana, was about 2740 people, with about 975 families. About 460 of those people lived in Venice.