Tytherington is an area in the north of Macclesfield in Cheshire, England. It comprises a large residential housing estate and has a church, Tytherington Family Worship Church, a foundation school, Tytherington School and a golf club. Tytherington Wood forms part of Macclesfield Riverside Park. Tytherington Business Park lies to the north-east.
Manchester Road divides the housing estate, the "Dorchester Way area" being to the west and "Rugby Drive area" to the east. Rugby Drive derives its name from Macclesfield Rugby Club, since relocated to Prestbury. The rugby pitch remains but is used predominately for football.
Tytherington has become a relatively affluent residential area, the average house price being around £320,000.