The municipality stands between 17°20' & 17°43' N and 99°15' & 99°28' W, some 20 km east of state capital Chilpancingo. It covers a total surface area of 290 km. It reported 33,620 people in the 2000 census, including 18% Native Americans (speakers of Nahuatl and Tlapaneco).
Tixtla was the birthplace of both Independence hero and Mexican president Vicente Guerrero (1783 - 1831) and writer and educator Ignacio Manuel Altamirano (1834 - 1893). It served as the first capital of Guerrero, from 1851 to 1870, and the state constitution was promulgated there on 14 June 1851.