Tishomingo is named after the Chickasaw chief, who signed the Treaty of Pontotoc in 1832. He served with General Anthony Wayne against the Shawnees in the Northwest Territory and received a silver medal from President George Washington. During the War of 1812, he served under Andrew Jackson. After his service in the military, he retired to become a farmer until white settlers came onto his land. In 1837, a final treaty forced the Chickasaws to move to the Indian Territory in present-day Oklahoma. Tishomingo died of smallpox on the Trail of Tears and is buried in Arkansas somewhere near Little Rock. His son, Iuka, is the namesake of the county seat of Tishomingo County, Mississippi.
The jazz standard "Tishomingo Blues" is named after Tishomingo.
National Register of Historic Places