Skerne is a village in the East Riding of Yorkshire, England. It now forms part of the civil parish of Skerne and Wansford. The village is situated 1 mile (1.6 km) to the south of the River Hull and the Driffield Canal. It is approximately 2 miles (3 km) south-east from Driffield and 2 miles north-east from Hutton Cranswick.
Historically, Skerne was an ecclesiastical parish in the wapentake of Harthill. From 1894 until 1974, Skerne was located in Driffield Rural District. The merger of Skerne with the neighbouring civil parish of Wansford occurred in 1935.
In 1974 most of what had been the East Riding of Yorkshire was joined with the northern part of Lincolnshire to became a new English county named Humberside. The urban and rural districts of the former counties were abolished and Humberside was divided into non-metropolitan districts. The new organization did not meet with the pleasure of the local citizenry and Humberside was wound up in 1996. The area north of the River Humber was separated into two "unitary authorities"—Kingston-upon-Hull covering the former City of Hull and its closest environs, and the less urban section which, once again, named itself the East Riding of Yorkshire.