São Francisco do Sul is a municipality in the Brazilian state of Santa Catarina. It covers an area of 540 km² (208 miles2) and had an estimated population of 42,569 in 2011. It was founded as a village by the Portuguese in 1658. It is situated on the northern end of the Island of São Francisco at the entrance to the Bay of Babitonga.
São Francisco do Sul is an important part of the Brazilian infrastructure. It provides large bulk shipping facilities and is served by the major container shipping lines connecting with the South American east and west coasts, Africa, Asia, North and Central America, the Caribbean and Europe.
During the past decade, São Francisco do Sul has become a popular tourism destination for South American and international guests.