Located 100 miles southwest of Little Rock, Prescott was constructed on the Prairie D'Ane, which consisted of approximately 25–30 square miles of rolling prairie, surrounded by forest. The area had been a well known crossroads prior to the construction of the Cairo & Fulton Railroad. To the west lies the city of Washington, to the east lies the city of Camden, while to the south lies the Red River, with Shreveport, Texarkana, and Dallas beyond.
As of 2014, Prescott and Nevada County had sixteen (16) properties listed on the National Register of Historic Places. Elkin's Ferry Battleground and the Prairie D'Ane Battlefield are further recognized as National Historic Landmarks.