Pouso Alegre is a city and municipality in southern region of Minas Gerais state, Brazil with a population of 127.974 (2009) of which 97.756 were urban and 9.020 were rural. The literacy rate is 94.2%. The area of the municipality is 541 km². It lies in the valley of the Sapucaí River.
Cities that form boundaries with Pouso Alegre are: Cachoeira de Minas, Santa Rita do Sapucaí, Careaçu, São Sebastião da Bela Vista, Estiva, Congonhal, São João da Mata and Silvianópolis.
Pouso Alegre is an industrial center with industries in the food sector, textiles, and metallurgy. Many national and multi-national enterprises have their plants here. Their activities include food (Unilever), clothing (Searchco), cars (Usiparts - Johnson Control's - Sumidenso), pharmaceuticals (Uniao Quimica, Sanobiol), glass (Sobral Invicta), and many other small and medium enterprises.
After discovering gold in the Santana's mines, they founded the new village called "Matosinho do Mandu", Pouso Alegre's first name. New paths were built to connect Pouso Alegre to other cities. These paths connected it to São Paulo and to Vila Rica.
In 1797 the Governor Dom Bernardo José de Lorena, Sarzedas Baron, passing by the small village became so enchanted by its nature, by "the vast and clean horizons", said "This village should not be called Mandu, but Pouso Alegre". In Portuguese, Pouso Alegre means "a nice stay".
The 2009 census of the city population was 131,462 inhabitants. The city is the nineteenth largest city in Minas Gerais and the second largest in southern Minas Gerais.
The city of Pouso Alegre stands out in the region by high buildings found in its central region. The highest building in the city is building Octávio Meyer, with 70m and 20 floors. It has been this way since 2004, the year of its completion.