Poughkeepsie , officially the Town of Poughkeepsie, is a town in Dutchess County, New York, United States. As of the 2010 United States Census, the population was 44,090, reflecting an increase of 1,313 from the 42,777 counted in the 2000 Census. The name is derived from the native term Uppuqui (oo-poo-kee) meaning lodge-covered, plus ipis meaning little water, plus ing meaning place, all of which translated to “the reed-covered lodge by the little water place,” or Uppuqui-ipis-ing. This later evolved into Apokeepsing, then into Poughkeepsing, and finally Poughkeepsie.
The town was first settled around 1780 and was part of the Schuyler Patent of 1788. The Town of Poughkeepsie was established in 1788 as part of a general organization of towns in the county. In 1854, part of the western section of the town, already an independent village, became the City of Poughkeepsie. At least two National Historic Landmarks are located in the town: the Vassar College Observatory and Main Building (Vassar College).