Port O'Connor (also known as P.O.C.) is an Unincorporated community in Calhoun County, Texas, United States, near the Gulf coastline between Galveston and Corpus Christi. The ZIP Code Tabulation Area including Port O'Connor had a population of 1,253  at the 2010 census. It is part of the Victoria, Texas Metropolitan Statistical Area.
Port O'Connor was laid out in the late 19th century as a fishing settlement called Alligator Head. As it grew in popularity with both permanent residents and tourists, the community took on more municipal like characteristics, earning the formal designation finally in 1912 as the town site of Port O'Connor. It was named after its main land owner at the time who was Thomas M. O'Connor who owned 70,000 acres (280 km²). Aside from local cattle herding and fishing, the town was also a producer of figs and citrus fruit.
Its initial population growth spanned the ten years from 1909 to 1919. Excursion trains used to run on weekends to Port O'Connor and an estimated 10,000 tourists came every summer.
Four times in the history of Port O'Connor it has been struck by hurricanes. The 1919 Florida Keys Hurricane brought the "good old days" to a halt, destroying the town. It rebuilt slowly but the 1942 and 1945 hurricanes so close in time were hard to overcome. In 1961 Port O'Connor was in the midst of another growth boom due to the increase of military personnel on nearby Matagorda Island Air Force Base (History of Matagorda Island). That same year Hurricane Carla destroyed the town again; but times reflect its will to survive, fueled by tourism, commercial fisheries and the petrochemical industry.