Otselic is a town in Chenango County, New York, United States, situated on the north border of Chenango County, northwest of the city of Norwich. The population of the town was 1,054 at the 2010 census. The town is named after a river flowing through it, the Otselic, which is an Oneida word for "place of wild plums". The Otselic valley is the predominant geographic feature in the town, connecting it to the surrounding region north and south.
The first settler arrived around 1800. Many of the original settlers came from Connecticut. The town of Otselic was founded in 1817 from part of the town of German. The year 1833 was notable for a tornado that passed over the town and measured over a mile in width.