Otatitlán is a city in the state of Veracruz, Mexico. It stands at , just across the state border from Tuxtepec, Oaxaca. The city serves as the municipal seat for the surrounding municipality of the same name.
In the year 2000 census, Otatitlán municipality reported a total population of 5,236, with 4,554 of those living in the city. The municipality's covers a total surface area of 53.46 km², and it is drained by the Río Obispo, a tributary of the Río Papaloapan.
A banana chip factory is also located there.