Nashik district has an area of 15,530 square kilometres. It is bounded by Dhule district to the north, Jalgaon district to the east, Aurangabad district to the southeast, Ahmadnagar district to the south, Thane district to the southwest, Valsad and Navsari districts of Gujarat to the west, and The Dangs district to the northwest.
The Western Ghats or Sahyadri range stretches from north to south across the western portion of the district. With the exception of the westernmost few villages, the western portion is hilly, and intersected by ravines, and only the simplest kind of cultivation is possible. The western slope of the Ghats is drained by several rivers, including the Daman Ganga River, which drains westwards to the Arabian Sea.
The larger eastern portion of the district, which lies on the Deccan Plateau, is open, fertile, and well cultivated. The Chander Range, which runs east and west, forms the chief divide of the plateau region. The Godavari River originates in the district and drains east towards the Bay of Bengal, and all the streams to the south of the Chander Range, including the Kadwa and Darna, are tributaries of the Godavari. To the north of the Chander Range, the Girna River and its tributary, the Mosam, flow eastward through fertile valleys into the Tapti River.