Nanjemoy is a settlement along Maryland Route 6 in southwestern Charles County, Maryland, United States, and the surrounding large rural area more or less bounded by Nanjemoy Creek to the east and north, and the Potomac River to the south and west. It and the creek draw their names from a Native American tribe. Nanjemoy is within the Washington, D.C., metropolitan area, being about 25 miles (40 km) south of the Capital Beltway (Interstates 95 and 495).
The village center includes a Post Office and a county-operated community center building that serves the area's population. Two children's camps and a sheriffs' training facility are also in the Nanjemoy area.
The area is served by Maryland Route 6 and other two-lane state highways; the nearest major roads are Maryland Route 210 to the north and U.S. Route 301 to the east. The Nanjemoy area is becoming increasingly popular with Washington-area commuters, particularly those working in nearby Indian Head or Fort Washington in Maryland or in Alexandria, Virginia. The Waldorf, Maryland, commercial area is nearby to the east, along U.S. 301. No rail lines presently serve the area.
Much of the Nanjemoy area is now forest or farmland. Tobacco was formerly commonly cultivated in the area, but is now rarely grown there. Other settlements in the Nanjemoy area include Grayton, Maryland Point, and Riverside. Chickamuxen, Doncaster, and Ironsides are nearby to the north.