Mebane is a city located mostly in Alamance County, North Carolina, United States, with a part of it in Orange County, North Carolina. The town was named for General Alexander Mebane, Jr., a Revolutionary War general and member of the U.S. Congress. It was incorporated as Mebanesville in 1881 and in 1883 the name was changed to Mebane. It was incorporated as a city in 1987. The population as of the 2010 census was 11,393.
The Alamance County portion is part of the Burlington Metropolitan Statistical Area, which is a component of the Greensboro-Winston-Salem-High Point Combined Statistical Area. The Orange County portion is part of the Durham-Chapel Hill Metropolitan Statistical Area, which is a component of the Raleigh-Durham-Chapel Hill Combined Statistical Area.