The town is served by Maybole railway station. The leading manufactures are of boots and shoes and agricultural implements. Two miles to the south-west are the ruins of Crossraguel (from Crois Riaghail meaning 'Cross of St Regulus' ) Abbey, founded about 1240.
Kirkoswald, where Robert Burns spent his seventeenth year, learning land-surveying, lies a little farther west. In the parish churchyard lie the real people who inspired two of Burn's fictitious characters Douglas Graham (Tam o' Shanter) and John Davidson (Souter Johnnie). Four miles to the west of Maybole on the coast is Culzean Castle, the chief seat of the marquess of Ailsa, dating from 1777; it stands on a basaltic cliff, beneath which are the Coves of Culzean, once the retreat of outlaws and a resort of the fairies. Farther south are the ruins of Turnberry Castle, where Robert the Bruce is said to have been born. A few miles to the north of Culzean are the ruins of Dunure Castle, an ancient stronghold of the Kennedys.
Margaret McMurray (??-1760), one of the last native speakers of a Lowland dialect of Scottish Gaelic is recorded to have lived at Cultezron (not to be confused with nearby Culzean), a farm on the outskirts of Maybole.
The secondary school for Maybole is Carrick Academy.
The local football club, Maybole F. C., play at Ladywell Stadium.
The lyrics of The Waterboys' 'Glastonbury Song' include:
"I dreamed myself from the sultry plains
To the old green square back in old Maybole ..."