Kruishoutem (in French and English Cruyshautem) is a municipality located in the Belgian province of East Flanders. The municipality comprises the towns of Kruishoutem proper, Nokere and Wannegem-Lede. On January 1, 2011, Kruishoutem had a total population of 8,140. The total area is 46.76 km² which gives a population density of 174 inhabitants per km².
The SONS Museum is located in Kruishoutem.