Hermann is a city designated in 1842 as the county seat of Gasconade County, Missouri, United States. It is near the center of the Missouri Rhineland and south of the Missouri River. The population was 2,431 at the 2010 census.
The city is the commercial center of the Hermann American Viticultural Area, whose seven wineries produce about one-third of the state's wine. Designated in 1983, it is one of the first federally recognized American Viticultural Areas. The designation recognized the renaissance of an area of vineyards and wineries established by German immigrants during the mid-19th century. Shut down by Prohibition, it began to revive in the 1960s.